The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells

Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) may account for cancer progression, recurrence, relapse. represent a distinct subpopulation in tumours detection, characterisation, understanding of regulatory landscape cellular processes that govern their maintenance pave way improving prognosis, selective targeted therapy, therapy outcomes. In this review, we have discussed characteristics identified various types role autophagy long noncoding RNAs (lncRNAs) maintaining homeostasis CSCs. Further, methods detect strategies treatment relapse, taking into requirement inhibit CSC growth survival within complex backdrop processes, microenvironmental interactions, networks associated with cancer. Finally, critique computationally reinforced triangle factors inclusive properties, process autophagy, lncRNA respect hypoxia, epithelial-to-mesenchymal transition (EMT), signalling pathways.